Buy 5-MeO-DMT is a natural psychedelic drug found in the venom of the Colorado River toad, Bufo Alvarius, also known as the Sonoran Desert toad. Smoking 5-MeO-DMT induces a short but intense psychedelic experience or ‘trip’, with hallucinogenic effects that are significantly stronger than those induced by DMT (the primary psychoactive molecule found in Ayahuasca). Despite this, the difference between 5-MeO-DMT and DMT is just a single Methoxy group, and it is structurally similar to other psychedelic drugs such as psilocybin and DMT.
Also present in at least nine families of plants, trees, and shrubs, use of 5-MeO-DMT as a psychedelic drug has been traced back some 3000 years in the form of crushed seeds known as ‘Yopo’, which are still used in spiritual ceremonies in Venezuela, Columbia, and Brazil. 5-MeO-DMT was first synthesised in 1936 by chemists Toshio Hoshino and Kenya Shimodaira and identified as an active component of Amazonian snuffs in 1959. Since then, 5-MeO-DMT has been detected in human blood, urine and cerebrospinal fluid.
Legal 5-MeO-DMT was readily available online as a ‘research chemical’, and grew increasingly popular before being made illegal in the USA in 2011, after which many other countries followed suit and banned the substance.
Due to these restrictions, research into 5-MeO-DMT is extremely limited and only a handful of studies have been conducted to date.
As a defence mechanism, the Colorado River Toad secretes a white milky substance called ‘Bufotoxin’ from areas behind its eyes called ‘parotoid glands’. When dried this contains up to 30% 5-MeO-DMT by mass, alongside other substances such as Bufotenine, DMT, NMT, DET, N-Methylserotonin and Bufogenin. There is no evidence of a difference between synthetic 5-MeO-DMT and that secreted by the Bufo Alvarius toad, meanwhile there are concerns regarding the environmental impact that Bufotoxin collection may be having on local toad populations at the United States and Mexico border.
The 5-MeO-DMT content of natural toad secretions can vary greatly between samples, which makes accurate dosing more difficult. This can be dangerous because 5-MeO-DMT is very powerful, even at low dosages, and the effects are highly dose-dependant, following a steep dose-response curve.
5-MeO-DMT is most commonly consumed in the form of a synthetic white, crystalline powder. Typical doses of 5-MeO-DMT are very small, typically 5mg, so care should always be taken by using accurate scales and researching the appropriate doses. 5-MeO-DMT in this form is typically either vapourised in a pipe and inhaled or less commonly insufflated (snorted).
Anadenanthera seeds (Yopo)
Some trees under the genus Anadenanthera contain 5-MeO-DMT. There is a long history of use of these seeds as shamanic snuffs in South America. Once the seeds have been toasted they are ground, sometimes mixed with other materials such as Ash and Tobacco, and forcefully blown up the nose of a user via a tube.